Schiff base derived from thiosemicarbazone and anthracene showed high potential in overcoming multidrug resistance in vitro with low drug resistance index

Multidrug resistance (MDR) is a huge obstacle in cancer chemotherapeutics. Overcoming MDR is a great challenge for anticancer drug discovery. Here, DNA binding and cytotoxicity of Schiff base L1 and L2 were explored to assess their efficiency in fighting cancer and overcoming the MDR. L1 and L2 coul...

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Detalles Bibliográficos
Autores principales: Bai, Jie, Wang, Rui-Hui, Qiao, Yan, Wang, Aidong, Fang, Chen-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546733/
https://www.ncbi.nlm.nih.gov/pubmed/28814831
http://dx.doi.org/10.2147/DDDT.S138371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546733/
https://www.ncbi.nlm.nih.gov/pubmed/28814831
http://dx.doi.org/10.2147/DDDT.S138371

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