Selective and regulated trapping of nicotinic receptor weak base ligands and relevance to smoking cessation

To better understand smoking cessation, we examined the actions of varenicline (Chantix) during long-term nicotine exposure. Varenicline reduced nicotine upregulation of α4β2-type nicotinic receptors (α4β2Rs) in live cells and neurons, but not for membrane preparations. Effects on upregulation depen...

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Detalles Bibliográficos
Autores principales: Govind, Anitha P, Vallejo, Yolanda F, Stolz, Jacob R, Yan, Jing-Zhi, Swanson, Geoffrey T, Green, William N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Human Biology and Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546804/
https://www.ncbi.nlm.nih.gov/pubmed/28718768
http://dx.doi.org/10.7554/eLife.25651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546804/
https://www.ncbi.nlm.nih.gov/pubmed/28718768
http://dx.doi.org/10.7554/eLife.25651

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