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Sequential neuromodulation of Hebbian plasticity offers mechanism for effective reward-based navigation

Spike timing-dependent plasticity (STDP) is under neuromodulatory control, which is correlated with distinct behavioral states. Previously, we reported that dopamine, a reward signal, broadens the time window for synaptic potentiation and modulates the outcome of hippocampal STDP even when applied a...

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Detalles Bibliográficos
Autores principales: Brzosko, Zuzanna, Zannone, Sara, Schultz, Wolfram, Clopath, Claudia, Paulsen, Ole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546805/
https://www.ncbi.nlm.nih.gov/pubmed/28691903
http://dx.doi.org/10.7554/eLife.27756