Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation

Current antiretroviral therapy (ART) for HIV/AIDS slows disease progression by reducing viral loads and increasing CD4 counts. Yet ART is not curative due to the persistence of CD4+ T-cell proviral reservoirs that chronically resupply active virus. Elimination of these reservoirs through the adminis...

Descripción completa

Detalles Bibliográficos
Autores principales: Albert, Brice J., Niu, Austin, Ramani, Rashmi, Marshall, Garland R., Wender, Paul A., Williams, Robert M., Ratner, Lee, Barnes, Alexander B., Kyei, George B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547048/
https://www.ncbi.nlm.nih.gov/pubmed/28785069
http://dx.doi.org/10.1038/s41598-017-07814-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547048/
https://www.ncbi.nlm.nih.gov/pubmed/28785069
http://dx.doi.org/10.1038/s41598-017-07814-4

Ejemplares similares