Clinical dosage of meclozine promotes longitudinal bone growth, bone volume, and trabecular bone quality in transgenic mice with achondroplasia

Achondroplasia (ACH) is the most common short-limbed skeletal dysplasia caused by gain-of-function mutations in the fibroblast growth factor receptor 3 (FGFR3). No effective FGFR3-targeted therapies for ACH are currently available. By drug repositioning strategies, we identified that meclozine, whic...

Descripción completa

Detalles Bibliográficos
Autores principales: Matsushita, Masaki, Esaki, Ryusaku, Mishima, Kenichi, Ishiguro, Naoki, Ohno, Kinji, Kitoh, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547068/
https://www.ncbi.nlm.nih.gov/pubmed/28785080
http://dx.doi.org/10.1038/s41598-017-07044-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547068/
https://www.ncbi.nlm.nih.gov/pubmed/28785080
http://dx.doi.org/10.1038/s41598-017-07044-8

Ejemplares similares