ssAAVs containing cassettes encoding SaCas9 and guides targeting hepatitis B virus inactivate replication of the virus in cultured cells

Management of infection with hepatitis B virus (HBV) remains a global health problem. Persistence of stable covalently closed circular DNA (cccDNA) during HBV replication is responsible for modest curative efficacy of currently licensed drugs. Novel gene editing technologies, such as those based on...

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Detalles Bibliográficos
Autores principales: Scott, Tristan, Moyo, Buhle, Nicholson, Samantha, Maepa, Mohube Betty, Watashi, Koichi, Ely, Abdullah, Weinberg, Marc S., Arbuthnot, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547162/
https://www.ncbi.nlm.nih.gov/pubmed/28785016
http://dx.doi.org/10.1038/s41598-017-07642-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547162/
https://www.ncbi.nlm.nih.gov/pubmed/28785016
http://dx.doi.org/10.1038/s41598-017-07642-6

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