stageR: a general stage-wise method for controlling the gene-level false discovery rate in differential expression and differential transcript usage

RNA sequencing studies with complex designs and transcript-resolution analyses involve multiple hypotheses per gene; however, conventional approaches fail to control the false discovery rate (FDR) at gene level. We propose stageR, a two-stage testing paradigm that leverages the increased power of ag...

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Detalles Bibliográficos
Autores principales: Van den Berge, Koen, Soneson, Charlotte, Robinson, Mark D., Clement, Lieven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547545/
https://www.ncbi.nlm.nih.gov/pubmed/28784146
http://dx.doi.org/10.1186/s13059-017-1277-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547545/
https://www.ncbi.nlm.nih.gov/pubmed/28784146
http://dx.doi.org/10.1186/s13059-017-1277-0

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