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stageR: a general stage-wise method for controlling the gene-level false discovery rate in differential expression and differential transcript usage
RNA sequencing studies with complex designs and transcript-resolution analyses involve multiple hypotheses per gene; however, conventional approaches fail to control the false discovery rate (FDR) at gene level. We propose stageR, a two-stage testing paradigm that leverages the increased power of ag...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547545/ https://www.ncbi.nlm.nih.gov/pubmed/28784146 http://dx.doi.org/10.1186/s13059-017-1277-0 |