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Simvastatin ameliorates ionizing radiation-induced apoptosis in the thymus by activating the AKT/sirtuin 1 pathway in mice

Simvastatin is a HMG-CoA reductase inhibitor widely used to lower plasma cholesterol and to protect against cardiovascular risk factors. The aim of this study was to investigate whether simvastatin attenuates ionizing radiation-induced damage in the mouse thymus and to elucidate the possible mechani...

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Detalles Bibliográficos
Autores principales: Yang, Hong, Huang, Fei, Tao, Yulong, Zhao, Xinbin, Liao, Lina, Tao, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547942/
https://www.ncbi.nlm.nih.gov/pubmed/28677744
http://dx.doi.org/10.3892/ijmm.2017.3047