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Wild-type blocking pcr coupled with internal competitive amplified fragment improved the detection of rare mutation of KRAS
Mutant KRAS proto-oncogene GTPase (KRAS) serves an important role in predicting the development, diagnosis, treatment and efficacy of targeted drug therapies for colorectal cancer. To improve the detection efficacy of trace amount of mutant KRAS, the locked nucleic acid-based method was modified in...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547944/ https://www.ncbi.nlm.nih.gov/pubmed/28677778 http://dx.doi.org/10.3892/mmr.2017.6883 |