Reverse translation of adverse event reports paves the way for de-risking preclinical off-targets

The Food and Drug Administration Adverse Event Reporting System (FAERS) remains the primary source for post-marketing pharmacovigilance. The system is largely un-curated, unstandardized, and lacks a method for linking drugs to the chemical structures of their active ingredients, increasing noise and...

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Detalles Bibliográficos
Autores principales: Maciejewski, Mateusz, Lounkine, Eugen, Whitebread, Steven, Farmer, Pierre, DuMouchel, William, Shoichet, Brian K, Urban, Laszlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Human Biology and Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548487/
https://www.ncbi.nlm.nih.gov/pubmed/28786378
http://dx.doi.org/10.7554/eLife.25818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548487/
https://www.ncbi.nlm.nih.gov/pubmed/28786378
http://dx.doi.org/10.7554/eLife.25818

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