TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice

Excess production of reactive oxygen species (ROS) caused by hyperglycemia is a major risk factor for heart failure. We previously reported that transient receptor potential canonical 3 (TRPC3) channel mediates pressure overload-induced maladaptive cardiac fibrosis by forming stably functional compl...

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Detalles Bibliográficos
Autores principales: Oda, Sayaka, Numaga-Tomita, Takuro, Kitajima, Naoyuki, Toyama, Takashi, Harada, Eri, Shimauchi, Tsukasa, Nishimura, Akiyuki, Ishikawa, Tatsuya, Kumagai, Yoshito, Birnbaumer, Lutz, Nishida, Motohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548754/
https://www.ncbi.nlm.nih.gov/pubmed/28790356
http://dx.doi.org/10.1038/s41598-017-07903-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548754/
https://www.ncbi.nlm.nih.gov/pubmed/28790356
http://dx.doi.org/10.1038/s41598-017-07903-4

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