Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations

The human genome encodes two active Vaccinia-related protein kinases (VRK), VRK1 and VRK2. These proteins have been implicated in a number of cellular processes and linked to a variety of tumors. However, understanding the cellular role of VRKs and establishing their potential use as targets for the...

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Detalles Bibliográficos
Autores principales: Couñago, Rafael M., Allerston, Charles K., Savitsky, Pavel, Azevedo, Hatylas, Godoi, Paulo H., Wells, Carrow I., Mascarello, Alessandra, de Souza Gama, Fernando H., Massirer, Katlin B., Zuercher, William J., Guimarães, Cristiano R. W., Gileadi, Opher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548783/
https://www.ncbi.nlm.nih.gov/pubmed/28790404
http://dx.doi.org/10.1038/s41598-017-07755-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548783/
https://www.ncbi.nlm.nih.gov/pubmed/28790404
http://dx.doi.org/10.1038/s41598-017-07755-y

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