Cargando…

Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations

The human genome encodes two active Vaccinia-related protein kinases (VRK), VRK1 and VRK2. These proteins have been implicated in a number of cellular processes and linked to a variety of tumors. However, understanding the cellular role of VRKs and establishing their potential use as targets for the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Couñago, Rafael M., Allerston, Charles K., Savitsky, Pavel, Azevedo, Hatylas, Godoi, Paulo H., Wells, Carrow I., Mascarello, Alessandra, de Souza Gama, Fernando H., Massirer, Katlin B., Zuercher, William J., Guimarães, Cristiano R. W., Gileadi, Opher
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548783/ https://www.ncbi.nlm.nih.gov/pubmed/28790404 http://dx.doi.org/10.1038/s41598-017-07755-y

Ejemplares similares

Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2
por: Serafim, Ricardo A. M., et al.
Publicado: (2019)

Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors
por: Santiago, André da Silva, et al.
Publicado: (2018)

Structural Characterization of Maize SIRK1 Kinase Domain Reveals an Unusual Architecture of the Activation Segment
por: Aquino, Bruno, et al.
Publicado: (2017)

Binding and structural analyses of potent inhibitors of the human Ca(2+)/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors
por: Profeta, Gerson S., et al.
Publicado: (2019)

The C-Terminal Domains SnRK2 Box and ABA Box Have a Role in Sugarcane SnRK2s Auto-Activation and Activity
por: Righetto, Germanna Lima, et al.
Publicado: (2019)

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes
por: Newman, Joseph A., et al.
Publicado: (2015)

Proteomics Identification of Nuclear Ran GTPase as an Inhibitor of Human VRK1 and VRK2 (Vaccinia-related Kinase) Activities
por: Sanz-García, Marta, et al.
Publicado: (2008)

Crystal structures of human soluble guanylate cyclase catalytic domains: promiscuity of the dimer interface and a potential allosteric site
por: Gileadi, Opher, et al.
Publicado: (2013)

Brain-wide mapping of c-fos expression in the single prolonged stress model and the effects of pretreatment with ACH-000029 or prazosin
por: Azevedo, Hatylas, et al.
Publicado: (2020)

Crystal Structures of the Catalytic Domain of Human Soluble Guanylate Cyclase
por: Allerston, Charles K., et al.
Publicado: (2013)

Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5
por: Newman, Joseph A., et al.
Publicado: (2017)

Dysregulation of Cellular VRK1, BAF, and Innate Immune Signaling by the Vaccinia Virus B12 Pseudokinase
por: Linville, Alexandria C., et al.
Publicado: (2022)

Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev: DETERMINANTS OF DNA BINDING AND REDOX REGULATION BY DISULFIDE BOND FORMATION
por: Cooper, Christopher D. O., et al.
Publicado: (2015)

Identification of LACTB2, a metallo-β-lactamase protein, as a human mitochondrial endoribonuclease
por: Levy, Shiri, et al.
Publicado: (2016)

Differential Inhibitor Sensitivity between Human Kinases VRK1 and VRK2
por: Vázquez-Cedeira, Marta, et al.
Publicado: (2011)

VRK1 Is a Synthetic–Lethal Target in VRK2-Deficient Glioblastoma
por: Shields, Julie A., et al.
Publicado: (2022)

DNA Aptamers against Vaccinia-Related Kinase (VRK) 1 Block Proliferation in MCF7 Breast Cancer Cells
por: Carrión-Marchante, Rebeca, et al.
Publicado: (2021)

Comparative Interactomes of VRK1 and VRK3 with Their Distinct Roles in the Cell Cycle of Liver Cancer
por: Lee, Namgyu, et al.
Publicado: (2017)

Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation
por: Keates, Tracy, et al.
Publicado: (2012)

The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities
por: Allerston, Charles K., et al.
Publicado: (2015)

VRK1 as a synthetic lethal target in VRK2 promoter–methylated cancers of the nervous system
por: So, Jonathan, et al.
Publicado: (2022)

MicroRNAs that interfere with RNAi
por: Massirer, Katlin B., et al.
Publicado: (2013)

A novel BRET-based assay to investigate binding and residence time of unmodified ligands to the human lysosomal ion channel TRPML1 in intact cells
por: Cunha, Micael R., et al.
Publicado: (2023)

Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response
por: Salzano, Marcella, et al.
Publicado: (2014)

Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development
por: Gileadi, Opher
Publicado: (2014)

WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop
por: Agajanian, Megan J., et al.
Publicado: (2019)

Autonomous pick-and-place using the dVRK
por: D’Ettorre, Claudia, et al.
Publicado: (2021)

VRK1 Kinase Activity Modulating Histone H4K16 Acetylation Inhibited by SIRT2 and VRK-IN-1
por: Monte-Serrano, Eva, et al.
Publicado: (2023)

The C/H3 Domain of p300 Is Required to Protect VRK1 and VRK2 from their Downregulation Induced by p53
por: Valbuena, Alberto, et al.
Publicado: (2008)

Functional characterization of lysosomal interaction of Akt with VRK2
por: Hirata, Noriyuki, et al.
Publicado: (2018)

Vrk1 partial Knockdown in Mice Results in Reduced Brain Weight and Mild Motor Dysfunction, and Indicates Neuronal VRK1 Target Pathways
por: Vinograd-Byk, Hadar, et al.
Publicado: (2018)

VRK1 functional insufficiency due to alterations in protein stability or kinase activity of human VRK1 pathogenic variants implicated in neuromotor syndromes
por: Martín-Doncel, Elena, et al.
Publicado: (2019)

High-throughput production of human proteins for crystallization: The SGC experience
por: Savitsky, Pavel, et al.
Publicado: (2010)

Crystal structure of DRIK1, a stress-responsive receptor-like pseudokinase, reveals the molecular basis for the absence of ATP binding
por: Aquino, Bruno, et al.
Publicado: (2020)

VRK-1 extends life span by activation of AMPK via phosphorylation
por: Park, Sangsoon, et al.
Publicado: (2020)

RecQ helicases in DNA repair and cancer targets
por: Newman, Joseph A., et al.
Publicado: (2020)

The miR-35-41 Family of MicroRNAs Regulates RNAi Sensitivity in Caenorhabditis elegans
por: Massirer, Katlin B., et al.
Publicado: (2012)

Characterization of the Human SNM1A and SNM1B/Apollo DNA Repair Exonucleases
por: Sengerová, Blanka, et al.
Publicado: (2012)

Data on the identification of VRK2 as a mediator of PD-1 function
por: Peled, Michael, et al.
Publicado: (2021)

Structural features and development of an assay platform of the parasite target deoxyhypusine synthase of Brugia malayi and Leishmania major
por: Silva, Suélen Fernandes, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_b8gg9cphnme6ei8ck179i1s8ui