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Evolution of new regulatory functions on biophysically realistic fitness landscapes
Gene expression is controlled by networks of regulatory proteins that interact specifically with external signals and DNA regulatory sequences. These interactions force the network components to co-evolve so as to continually maintain function. Yet, existing models of evolution mostly focus on isola...
Autores principales: | Friedlander, Tamar, Prizak, Roshan, Barton, Nicholas H., Tkačik, Gašper |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548793/ https://www.ncbi.nlm.nih.gov/pubmed/28790313 http://dx.doi.org/10.1038/s41467-017-00238-8 |
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