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Transcriptome profiling of mouse brains with qkI-deficient oligodendrocytes reveals major alternative splicing defects including self-splicing

The qkI gene encodes a family of RNA binding proteins alternatively spliced at its 3′ end, giving rise to three major spliced isoforms: QKI-5, QKI-6 and QKI-7. Their expression is tightly regulated during brain development with nuclear QKI-5 being the most abundant during embryogenesis followed by Q...

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Detalles Bibliográficos
Autores principales: Darbelli, Lama, Choquet, Karine, Richard, Stéphane, Kleinman, Claudia L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548867/
https://www.ncbi.nlm.nih.gov/pubmed/28790308
http://dx.doi.org/10.1038/s41598-017-06211-1