Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI

RING-in-between-RING (RBR) ubiquitin (Ub) E3 ligases function with Ub E2s through a RING/HECT hybrid mechanism to conjugate Ub to target proteins. Here, we report the crystal structure of the RBR E3, HHARI, in complex with a UbcH7 ~ Ub thioester mimetic which reveals the molecular basis for the spec...

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Detalles Bibliográficos
Autores principales: Yuan, Lingmin, Lv, Zongyang, Atkison, James H., Olsen, Shaun K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548887/
https://www.ncbi.nlm.nih.gov/pubmed/28790309
http://dx.doi.org/10.1038/s41467-017-00272-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548887/
https://www.ncbi.nlm.nih.gov/pubmed/28790309
http://dx.doi.org/10.1038/s41467-017-00272-6

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