P16(INK4a) Deletion Ameliorated Renal Tubulointerstitial Injury in a Stress-induced Premature Senescence Model of Bmi-1 Deficiency

To determine whether p16 (INK4a) deletion ameliorated renal tubulointerstitial injury by inhibiting a senescence-associated secretory phenotype (SASP) in Bmi-1-deficient (Bmi-1 (−/−)) mice, renal phenotypes were compared among 5-week-old Bmi-1 and p16 (INK4a) double-knockout, and Bmi-1 (−/−) and wil...

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Detalles Bibliográficos
Autores principales: Jin, Jianliang, Tao, Jianguo, Gu, Xin, Yu, Zhenzhen, Wang, Rong, Zuo, Guoping, Li, Qing, Lv, Xianhui, Miao, Dengshun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548892/
https://www.ncbi.nlm.nih.gov/pubmed/28790310
http://dx.doi.org/10.1038/s41598-017-06868-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548892/
https://www.ncbi.nlm.nih.gov/pubmed/28790310
http://dx.doi.org/10.1038/s41598-017-06868-8

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