Novel animal model defines genetic contributions for neuron-to-neuron transfer of α-synuclein

Cell-to-cell spreading of misfolded α-synuclein (α-syn) is suggested to contribute to the progression of neuropathology in Parkinson’s disease (PD). Compelling evidence supports the hypothesis that misfolded α-syn transmits from neuron-to-neuron and seeds aggregation of the protein in the recipient...

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Detalles Bibliográficos
Autores principales: Tyson, Trevor, Senchuk, Megan, Cooper, Jason F., George, Sonia, Van Raamsdonk, Jeremy M., Brundin, Patrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548897/
https://www.ncbi.nlm.nih.gov/pubmed/28790319
http://dx.doi.org/10.1038/s41598-017-07383-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548897/
https://www.ncbi.nlm.nih.gov/pubmed/28790319
http://dx.doi.org/10.1038/s41598-017-07383-6

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