KDM4B-mediated reduction of H3K9me3 and H3K36me3 levels improves somatic cell reprogramming into pluripotency

Correct reprogramming of epigenetic marks is essential for somatic cells to regain pluripotency. Repressive histone (H) lysine (K) methylation marks are known to be stable and difficult to reprogram. In this study, we generated transgenic mice and mouse embryonic fibroblasts (MEFs) for the inducible...

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Detalles Bibliográficos
Autores principales: Wei, Jingwei, Antony, Jisha, Meng, Fanli, MacLean, Paul, Rhind, Rebekah, Laible, Götz, Oback, Björn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548918/
https://www.ncbi.nlm.nih.gov/pubmed/28790329
http://dx.doi.org/10.1038/s41598-017-06569-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548918/
https://www.ncbi.nlm.nih.gov/pubmed/28790329
http://dx.doi.org/10.1038/s41598-017-06569-2

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