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Determination of the endothelin-1 recognition sites of endothelin receptor type A by the directed-degeneration method
G-protein coupled receptors (GPCRs) play indispensable physiological roles in cell proliferation, differentiation, and migration; therefore, identifying the mechanisms by which ligands bind to GPCRs is crucial for developing GPCR-targeting pharmaceutics and for understanding critical biological func...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548930/ https://www.ncbi.nlm.nih.gov/pubmed/28790412 http://dx.doi.org/10.1038/s41598-017-08096-6 |