Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome

Excessive mRNA translation downstream of group I metabotropic glutamate receptors (mGlu(1/5)) is a core pathophysiology of fragile X syndrome (FX); however, the differentially translating mRNAs that contribute to altered neural function are not known. We used translating ribosome affinity purificati...

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Detalles Bibliográficos
Autores principales: Thomson, Sophie R., Seo, Sang S., Barnes, Stephanie A., Louros, Susana R., Muscas, Melania, Dando, Owen, Kirby, Caoimhe, Wyllie, David J.A., Hardingham, Giles E., Kind, Peter C., Osterweil, Emily K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548955/
https://www.ncbi.nlm.nih.gov/pubmed/28772121
http://dx.doi.org/10.1016/j.neuron.2017.07.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548955/
https://www.ncbi.nlm.nih.gov/pubmed/28772121
http://dx.doi.org/10.1016/j.neuron.2017.07.013

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