Cargando…

Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome

Excessive mRNA translation downstream of group I metabotropic glutamate receptors (mGlu(1/5)) is a core pathophysiology of fragile X syndrome (FX); however, the differentially translating mRNAs that contribute to altered neural function are not known. We used translating ribosome affinity purificati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thomson, Sophie R., Seo, Sang S., Barnes, Stephanie A., Louros, Susana R., Muscas, Melania, Dando, Owen, Kirby, Caoimhe, Wyllie, David J.A., Hardingham, Giles E., Kind, Peter C., Osterweil, Emily K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548955/ https://www.ncbi.nlm.nih.gov/pubmed/28772121 http://dx.doi.org/10.1016/j.neuron.2017.07.013

Ejemplares similares

Lovastatin, not Simvastatin, Corrects Core Phenotypes in the Fragile X Mouse Model
por: Muscas, Melania, et al.
Publicado: (2019)

Excess ribosomal protein production unbalances translation in a model of Fragile X Syndrome
por: Seo, Sang S., et al.
Publicado: (2022)

A Differential Effect of Lovastatin versus Simvastatin in Neurodevelopmental Disorders
por: Muscas, Melania, et al.
Publicado: (2020)

Altered dendritic spine function and integration in a mouse model of fragile X syndrome
por: Booker, Sam A., et al.
Publicado: (2019)

Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome
por: Booker, Sam A., et al.
Publicado: (2020)

Perturbed proteostasis in autism spectrum disorders
por: Louros, Susana R., et al.
Publicado: (2016)

Differential splicing choices made by neurons and astrocytes and their importance when investigating signal-dependent alternative splicing in neural cells
por: Baxter, Paul S., et al.
Publicado: (2023)

Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome
por: Asiminas, Antonis, et al.
Publicado: (2022)

Is metabotropic glutamate receptor 5 upregulated in prefrontal cortex in fragile X syndrome?
por: Lohith, Talakad G, et al.
Publicado: (2013)

Ionotropic GABA and glycine receptor subunit composition in human pluripotent stem cell-derived excitatory cortical neurones
por: James, Owain T, et al.
Publicado: (2014)

Secondary injury and inflammation after intracerebral haemorrhage: a systematic review and meta-analysis of molecular markers in patient brain tissue
por: Loan, James JM, et al.
Publicado: (2022)

Translation in fragile X: no home runs in the first at-bat
por: Veenstra-VanderWeele, Jeremy
Publicado: (2017)

Experiential contributions to social dominance in a rat model of fragile-X syndrome
por: Saxena, K., et al.
Publicado: (2018)

Expression of mRNA Encoding Mcu and Other Mitochondrial Calcium Regulatory Genes Depends on Cell Type, Neuronal Subtype, and Ca(2+) Signaling
por: Márkus, Nóra M., et al.
Publicado: (2016)

Editorial: Recent advances in mechanisms and therapeutics for Fragile X Syndrome and autism
por: Molinaro, Gemma, et al.
Publicado: (2023)

Fragile X Mental Retardation Protein: To Be or Not to Be a Translational Enhancer
por: Maurin, Thomas, et al.
Publicado: (2018)

Neuronal Activity and Its Role in Controlling Antioxidant Genes
por: Qiu, Jing, et al.
Publicado: (2020)

Targeting fragile X
por: Gantois, Ilse, et al.
Publicado: (2002)

Fragile X syndrome and fragile X-associated disorders
por: Rajaratnam, Akash, et al.
Publicado: (2017)

Targeted de-repression of neuronal Nrf2 inhibits α-synuclein accumulation
por: Baxter, Paul S., et al.
Publicado: (2021)

EEG as a translational biomarker and outcome measure in fragile X syndrome
por: Kenny, Aisling, et al.
Publicado: (2022)

Microglial identity and inflammatory responses are controlled by the combined effects of neurons and astrocytes
por: Baxter, Paul S., et al.
Publicado: (2021)

Fragile X/Cancer Cytogenetics
por: Seashore, Margretta R.
Publicado: (1992)

Identification and functional modelling of plausibly causative cis-regulatory variants in a highly-selected cohort with X-linked intellectual disability
por: Bengani, Hemant, et al.
Publicado: (2021)

A Novel Function for Fragile X Mental Retardation Protein in Translational Activation
por: Bechara, Elias G, et al.
Publicado: (2009)

Neuropathology of RAN translation proteins in fragile X-associated tremor/ataxia syndrome
por: Krans, Amy, et al.
Publicado: (2019)

Fragile X Syndrome
por: McLennan, Yingratana, et al.
Publicado: (2011)

Fragile X Premutation
por: Tassone, Flora, et al.
Publicado: (2014)

Fragile X Syndrome
por: Saldarriaga, Wilmar, et al.
Publicado: (2014)

Conserved hippocampal cellular pathophysiology but distinct behavioural deficits in a new rat model of FXS
por: Till, Sally M., et al.
Publicado: (2015)

General anesthesia alters CNS and astrocyte expression of activity-dependent and activity-independent genes
por: Jiwaji, Zoeb, et al.
Publicado: (2023)

A native function for RAN translation and CGG repeats in regulating Fragile X protein synthesis
por: Rodriguez, Caitlin M., et al.
Publicado: (2020)

Functional assessment of the NMDA receptor variant GluN2A (R586K)
por: Marwick, Katie F.M., et al.
Publicado: (2017)

Psychosis and Catatonia in Fragile X Syndrome
por: Keshtkarjahromi, Mitra, et al.
Publicado: (2021)

Mouse models of the fragile X premutation and fragile X-associated tremor/ataxia syndrome
por: Berman, Robert F, et al.
Publicado: (2014)

Fragile X-Associated Neuropsychiatric Disorders (FXAND) in Young Fragile X Premutation Carriers
por: Aishworiya, Ramkumar, et al.
Publicado: (2022)

NMDA Receptor C-Terminal Domain Signalling in Development, Maturity, and Disease
por: Haddow, Kirsty, et al.
Publicado: (2022)

Impaired Attention Orienting in Young Children With Fragile X Syndrome
por: Chernenok, Mariya, et al.
Publicado: (2019)

Recovery of NMDA receptor currents from MK-801 blockade is accelerated by Mg(2+) and memantine under conditions of agonist exposure
por: McKay, Sean, et al.
Publicado: (2013)

Aging in fragile X syndrome
por: Utari, Agustini, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_l6ivd68fstsqa1scdo7tere91f