MYC is a positive regulator of choline metabolism and impedes mitophagy-dependent necroptosis in diffuse large B-cell lymphoma

The activation of oncogenes can reprogram tumor cell metabolism. Here, in diffuse large B-cell lymphoma (DLBCL), serum metabolomic analysis revealed that oncogenic MYC could induce aberrant choline metabolism by transcriptionally activating the key enzyme phosphate cytidylyltransferase 1 choline-α (...

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Detalles Bibliográficos
Autores principales: Xiong, J, Wang, L, Fei, X-C, Jiang, X-F, Zheng, Z, Zhao, Y, Wang, C-F, Li, B, Chen, S-J, Janin, A, Gale, R P, Zhao, W-L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549253/
https://www.ncbi.nlm.nih.gov/pubmed/28686226
http://dx.doi.org/10.1038/bcj.2017.61

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549253/
https://www.ncbi.nlm.nih.gov/pubmed/28686226
http://dx.doi.org/10.1038/bcj.2017.61

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