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Serum high mobility group box-1 and osteoprotegerin levels are associated with peripheral arterial disease and critical limb ischemia in type 2 diabetic subjects
BACKGROUND: High mobility group box-1 (HMGB-1) is a nuclear protein also acting as inflammatory mediator, whilst osteoprotegerin (OPG), member of tumor necrosis factor receptor superfamily, is indicated as marker of vascular calcification. Peripheral artery disease (PAD) and type 2 diabetes (T2D) ar...
Autores principales: | Giovannini, Silvia, Tinelli, Giovanni, Biscetti, Federico, Straface, Giuseppe, Angelini, Flavia, Pitocco, Dario, Mucci, Luciana, Landolfi, Raffaele, Flex, Andrea |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549317/ https://www.ncbi.nlm.nih.gov/pubmed/28789654 http://dx.doi.org/10.1186/s12933-017-0581-z |
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