Choice of futility boundaries for group sequential designs with two endpoints

BACKGROUND: In clinical trials, the opportunity for an early stop during an interim analysis (either for efficacy or for futility) may relevantly save time and financial resources. This is especially important, if the planning assumptions required for power calculation are based on a low level of ev...

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Detalles Bibliográficos
Autores principales: Schüler, Svenja, Kieser, Meinhard, Rauch, Geraldine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549398/
https://www.ncbi.nlm.nih.gov/pubmed/28789615
http://dx.doi.org/10.1186/s12874-017-0387-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549398/
https://www.ncbi.nlm.nih.gov/pubmed/28789615
http://dx.doi.org/10.1186/s12874-017-0387-4

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