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Choice of futility boundaries for group sequential designs with two endpoints
BACKGROUND: In clinical trials, the opportunity for an early stop during an interim analysis (either for efficacy or for futility) may relevantly save time and financial resources. This is especially important, if the planning assumptions required for power calculation are based on a low level of ev...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549398/ https://www.ncbi.nlm.nih.gov/pubmed/28789615 http://dx.doi.org/10.1186/s12874-017-0387-4 |