2-Deoxy-D-glucose Restore Glucocorticoid Sensitivity in Acute Lymphoblastic Leukemia via Modification of N-Linked Glycosylation in an Oxygen Tension-Independent Manner

In childhood acute lymphoblastic leukemia, treatment failure is associated with resistance to glucocorticoid agents. Resistance to this class of drugs represents one of the strongest indicators of poor clinical outcome. We show that leukemic cells, which are resistant to the glucocorticoid drug meth...

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Detalles Bibliográficos
Autores principales: Leni, Zaira, Ćwiek, Paulina, Dimitrova, Valeriya, Dulcey, Andrea S., Zamboni, Nicola, Simillion, Cedric, Rossi, Geetha, Leibundgut, Kurt, Arcaro, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549481/
https://www.ncbi.nlm.nih.gov/pubmed/28814986
http://dx.doi.org/10.1155/2017/2487297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549481/
https://www.ncbi.nlm.nih.gov/pubmed/28814986
http://dx.doi.org/10.1155/2017/2487297

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