Multiregional Tumor Trees Are Not Phylogenies

Tumor samples most often comprise a mixture of different cell lineages. Multiregional trees built from bulk mutational profiles do not consider this heterogeneity and can potentially lead to erroneous evolutionary inferences, including biased timing of somatic mutations, spurious parallel mutation e...

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Detalles Bibliográficos
Autores principales: Alves, João M., Prieto, Tamara, Posada, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Forum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549612/
https://www.ncbi.nlm.nih.gov/pubmed/28780931
http://dx.doi.org/10.1016/j.trecan.2017.06.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549612/
https://www.ncbi.nlm.nih.gov/pubmed/28780931
http://dx.doi.org/10.1016/j.trecan.2017.06.004

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