Engineering double-stranded RNA binding activity into the Drosha double-stranded RNA binding domain results in a loss of microRNA processing function

Canonical processing of miRNA begins in the nucleus with the Microprocessor complex, which is minimally composed of the RNase III enzyme Drosha and two copies of its cofactor protein DGCR8. In structural analogy to most RNase III enzymes, Drosha possesses a modular domain with the double-stranded RN...

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Detalles Bibliográficos
Autores principales: Kranick, Joshua C., Chadalavada, Durga M., Sahu, Debashish, Showalter, Scott A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549741/
https://www.ncbi.nlm.nih.gov/pubmed/28792523
http://dx.doi.org/10.1371/journal.pone.0182445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549741/
https://www.ncbi.nlm.nih.gov/pubmed/28792523
http://dx.doi.org/10.1371/journal.pone.0182445

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