Switching of dominant retrotransposon silencing strategies from posttranscriptional to transcriptional mechanisms during male germ-cell development in mice

Mammalian genomes harbor millions of retrotransposon copies, some of which are transpositionally active. In mouse prospermatogonia, PIWI-interacting small RNAs (piRNAs) combat retrotransposon activity to maintain the genomic integrity. The piRNA system destroys retrotransposon-derived RNAs and guide...

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Detalles Bibliográficos
Autores principales: Inoue, Kota, Ichiyanagi, Kenji, Fukuda, Kei, Glinka, Michael, Sasaki, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549759/
https://www.ncbi.nlm.nih.gov/pubmed/28749988
http://dx.doi.org/10.1371/journal.pgen.1006926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549759/
https://www.ncbi.nlm.nih.gov/pubmed/28749988
http://dx.doi.org/10.1371/journal.pgen.1006926

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