RBP4-STRA6 Pathway Drives Cancer Stem Cell Maintenance and Mediates High-Fat Diet-Induced Colon Carcinogenesis

The transmembrane protein, STRA6, functions as a vitamin A transporter and a cytokine receptor when activated by vitamin A-bound serum retinol binding protein 4 (RBP4). STRA6 activation transduces a JAK2-STAT3 signaling cascade and promotes tumorigenesis in a xenograft mouse model of colon cancer. W...

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Detalles Bibliográficos
Autores principales: Karunanithi, Sheelarani, Levi, Liraz, DeVecchio, Jennifer, Karagkounis, George, Reizes, Ofer, Lathia, Justin D., Kalady, Matthew F., Noy, Noa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549806/
https://www.ncbi.nlm.nih.gov/pubmed/28689994
http://dx.doi.org/10.1016/j.stemcr.2017.06.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549806/
https://www.ncbi.nlm.nih.gov/pubmed/28689994
http://dx.doi.org/10.1016/j.stemcr.2017.06.002

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