Orofacial neuropathic pain induced by oxaliplatin: Downregulation of KCNQ2 channels in V2 trigeminal ganglion neurons and treatment by the KCNQ2 channel potentiator retigabine

Neuropathic pain induced by chemotherapy drugs such as oxaliplatin is a dose-limiting side effect in cancer treatment. The mechanisms underlying chemotherapy-induced neuropathic pain are not fully understood. KCNQ2 channels are low-threshold voltage-gated K(+) channels that play a role in controllin...

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Detalles Bibliográficos
Autores principales: Ling, Jennifer, Erol, Ferhat, Viatchenko-Karpinski, Viacheslav, Kanda, Hirosato, Gu, Jianguo G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549876/
https://www.ncbi.nlm.nih.gov/pubmed/28741430
http://dx.doi.org/10.1177/1744806917724715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549876/
https://www.ncbi.nlm.nih.gov/pubmed/28741430
http://dx.doi.org/10.1177/1744806917724715

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