Identification of the primary peptide contaminant that inhibits fibrillation and toxicity in synthetic amyloid-β42

Understanding the pathophysiology of Alzheimer disease has relied upon the use of amyloid peptides from a variety of sources, but most predominantly synthetic peptides produced using t-butyloxycarbonyl (Boc) or 9-fluorenylmethoxycarbonyl (Fmoc) chemistry. These synthetic methods can lead to minor im...

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Detalles Bibliográficos
Autores principales: Adams, Daniel J., Nemkov, Travis G., Mayer, John P., Old, William M., Stowell, Michael H. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549942/
https://www.ncbi.nlm.nih.gov/pubmed/28792968
http://dx.doi.org/10.1371/journal.pone.0182804

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549942/
https://www.ncbi.nlm.nih.gov/pubmed/28792968
http://dx.doi.org/10.1371/journal.pone.0182804

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