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Automated incorporation of pairwise dependency in transcription factor binding site prediction using dinucleotide weight tensors

Gene regulatory networks are ultimately encoded by the sequence-specific binding of (TFs) to short DNA segments. Although it is customary to represent the binding specificity of a TF by a position-specific weight matrix (PSWM), which assumes each position within a site contributes independently to t...

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Detalles Bibliográficos
Autores principales: Omidi, Saeed, Zavolan, Mihaela, Pachkov, Mikhail, Breda, Jeremie, Berger, Severin, van Nimwegen, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550003/
https://www.ncbi.nlm.nih.gov/pubmed/28753602
http://dx.doi.org/10.1371/journal.pcbi.1005176