Essential roles of Caspase-3 in facilitating Myc-induced genetic instability and carcinogenesis

The mechanism for Myc-induced genetic instability is not well understood. Here we show that sublethal activation of Caspase-3 plays an essential, facilitative role in Myc-induced genomic instability and oncogenic transformation. Overexpression of Myc resulted in increased numbers of chromosome aberr...

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Detalles Bibliográficos
Autores principales: Cartwright, Ian M, Liu, Xinjian, Zhou, Min, Li, Fang, Li, Chuan-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550274/
https://www.ncbi.nlm.nih.gov/pubmed/28691902
http://dx.doi.org/10.7554/eLife.26371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550274/
https://www.ncbi.nlm.nih.gov/pubmed/28691902
http://dx.doi.org/10.7554/eLife.26371

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