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Measuring inter-protein pairwise interaction energies from a single native mass spectrum by double-mutant cycle analysis
The strength and specificity of protein complex formation is crucial for most life processes and is determined by interactions between residues in the binding partners. Double-mutant cycle analysis provides a strategy for studying the energetic coupling between amino acids at the interfaces of such...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550451/ https://www.ncbi.nlm.nih.gov/pubmed/28794496 http://dx.doi.org/10.1038/s41467-017-00285-1 |