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Effect of uridine protecting groups on the diastereoselectivity of uridine-derived aldehyde 5’-alkynylation
The 5’-alkynylation of uridine-derived aldehydes is described. The addition of alkynyl Grignard reagents on the carbonyl group is significantly influenced by the 2’,3’-di-O-protecting groups (R(1)): O-alkyl groups led to modest diastereoselectivities (65:35) in favor of the 5’R-isomer, whereas O-sil...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550804/ https://www.ncbi.nlm.nih.gov/pubmed/28845198 http://dx.doi.org/10.3762/bjoc.13.153 |