Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain

Our previous findings suggest that sphingosine kinase 2 (SPK2) mediates ischemic tolerance and autophagy in cerebral preconditioning. The aim of this study was to determine by which mechanism SPK2 activates autophagy in neural cells. In both primary murine cortical neurons and HT22 hippocampal neuro...

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Detalles Bibliográficos
Autores principales: Song, Dan-Dan, Zhang, Tong-Tong, Chen, Jia-Li, Xia, Yun-Fei, Qin, Zheng-Hong, Waeber, Christian, Sheng, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550846/
https://www.ncbi.nlm.nih.gov/pubmed/28682313
http://dx.doi.org/10.1038/cddis.2017.289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550846/
https://www.ncbi.nlm.nih.gov/pubmed/28682313
http://dx.doi.org/10.1038/cddis.2017.289

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