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Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain
Our previous findings suggest that sphingosine kinase 2 (SPK2) mediates ischemic tolerance and autophagy in cerebral preconditioning. The aim of this study was to determine by which mechanism SPK2 activates autophagy in neural cells. In both primary murine cortical neurons and HT22 hippocampal neuro...
Autores principales: | Song, Dan-Dan, Zhang, Tong-Tong, Chen, Jia-Li, Xia, Yun-Fei, Qin, Zheng-Hong, Waeber, Christian, Sheng, Rui |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550846/ https://www.ncbi.nlm.nih.gov/pubmed/28682313 http://dx.doi.org/10.1038/cddis.2017.289 |
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