mTORC2 regulates hedgehog pathway activity by promoting stability to Gli2 protein and its nuclear translocation

mTORC2 is aberrantly activated in cancer and therefore is considered to be an important therapeutic target. The hedgehog pathway, which is also often hyperactivated, regulates transcription of several genes associated with angiogenesis, metastasis, cellular proliferation and cancer stem cell (CSC) r...

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Detalles Bibliográficos
Autores principales: Maiti, Samarpan, Mondal, Susmita, Satyavarapu, Eswara M, Mandal, Chitra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550848/
https://www.ncbi.nlm.nih.gov/pubmed/28703798
http://dx.doi.org/10.1038/cddis.2017.296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550848/
https://www.ncbi.nlm.nih.gov/pubmed/28703798
http://dx.doi.org/10.1038/cddis.2017.296

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