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mTORC2 regulates hedgehog pathway activity by promoting stability to Gli2 protein and its nuclear translocation
mTORC2 is aberrantly activated in cancer and therefore is considered to be an important therapeutic target. The hedgehog pathway, which is also often hyperactivated, regulates transcription of several genes associated with angiogenesis, metastasis, cellular proliferation and cancer stem cell (CSC) r...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550848/ https://www.ncbi.nlm.nih.gov/pubmed/28703798 http://dx.doi.org/10.1038/cddis.2017.296 |