Binding of doxorubicin to Sorcin impairs cell death and increases drug resistance in cancer cells

Sorcin is a calcium binding protein that plays an important role in multidrug resistance (MDR) in tumors, since its expression confers resistance to doxorubicin and to other chemotherapeutic drugs. In this study, we show that Sorcin is able to bind doxorubicin, vincristine, paclitaxel and cisplatin...

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Detalles Bibliográficos
Autores principales: Genovese, Ilaria, Fiorillo, Annarita, Ilari, Andrea, Masciarelli, Silvia, Fazi, Francesco, Colotti, Gianni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550883/
https://www.ncbi.nlm.nih.gov/pubmed/28726784
http://dx.doi.org/10.1038/cddis.2017.342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550883/
https://www.ncbi.nlm.nih.gov/pubmed/28726784
http://dx.doi.org/10.1038/cddis.2017.342

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