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Acid sphingomyelinase mediates human CD4(+) T-cell signaling: potential roles in T-cell responses and diseases
Acid sphingomyelinase (ASM) is a lipid hydrolase. By generating ceramide, ASM had been reported to have an important role in regulating immune cell functions inclusive of macrophages, NK cells, and CD8(+) T cells, whereas the role of ASM bioactivity in regulation of human CD4(+) T-cell functions rem...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550889/ https://www.ncbi.nlm.nih.gov/pubmed/28749465 http://dx.doi.org/10.1038/cddis.2017.360 |