[6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucose-stimulated insulin secretion pathway in pancreatic β-cells and increases RAB8/RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Lepr(db/db) type 2 diabetic mice

BACKGROUND: [6]-Gingerol, a major component of Zingiber officinale, was previously reported to ameliorate hyperglycemia in type 2 diabetic mice. Endocrine signaling is involved in insulin secretion and is perturbed in db/db Type-2 diabetic mice. [6]-Gingerol was reported to restore the disrupted end...

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Detalles Bibliográficos
Autores principales: Samad, Mehdi Bin, Mohsin, Md. Nurul Absar Bin, Razu, Bodiul Alam, Hossain, Mohammad Tashnim, Mahzabeen, Sinayat, Unnoor, Naziat, Muna, Ishrat Aklima, Akhter, Farjana, Kabir, Ashraf Ul, Hannan, J. M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550996/
https://www.ncbi.nlm.nih.gov/pubmed/28793909
http://dx.doi.org/10.1186/s12906-017-1903-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550996/
https://www.ncbi.nlm.nih.gov/pubmed/28793909
http://dx.doi.org/10.1186/s12906-017-1903-0

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