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Berberine Depresses Contraction of Smooth Muscle via Inhibiting Myosin Light-chain Kinase

BACKGROUND: Berberine is a natural isoquinoline alkaloid possessing various pharmacological effects, particularly apparent in the treatment of diarrhea, but the underlying mechanism remains unclear. Smooth muscle myosin light-chain kinase (MLCK) plays a crucial role in the smooth muscle relaxation-c...

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Detalles Bibliográficos
Autores principales: Xu, Zhili, Zhang, Mingbo, Dou, Deqiang, Tao, Xiaojun, Kang, Tingguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551364/
https://www.ncbi.nlm.nih.gov/pubmed/28839371
http://dx.doi.org/10.4103/pm.pm_205_16