Hypoxia Downregulates MAPK/ERK but Not STAT3 Signaling in ROS-Dependent and HIF-1-Independent Manners in Mouse Embryonic Stem Cells

Hypoxia is involved in the regulation of stem cell fate, and hypoxia-inducible factor 1 (HIF-1) is the master regulator of hypoxic response. Here, we focus on the effect of hypoxia on intracellular signaling pathways responsible for mouse embryonic stem (ES) cell maintenance. We employed wild-type a...

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Detalles Bibliográficos
Autores principales: Kučera, Jan, Netušilová, Julie, Sladeček, Stanislava, Lánová, Martina, Vašíček, Ondřej, Štefková, Kateřina, Navrátilová, Jarmila, Kubala, Lukáš, Pacherník, Jiří
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551543/
https://www.ncbi.nlm.nih.gov/pubmed/28819544
http://dx.doi.org/10.1155/2017/4386947

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551543/
https://www.ncbi.nlm.nih.gov/pubmed/28819544
http://dx.doi.org/10.1155/2017/4386947

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