Thymic progenitors of TCRαβ(+) CD8αα intestinal intraepithelial lymphocytes require RasGRP1 for development

Strong T cell receptor (TCR) signaling largely induces cell death during thymocyte development, whereas weak TCR signals induce positive selection. However, some T cell lineages require strong TCR signals for differentiation through a process termed agonist selection. The signaling relationships tha...

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Detalles Bibliográficos
Autores principales: Golec, Dominic P., Hoeppli, Romy E., Henao Caviedes, Laura M., McCann, Jillian, Levings, Megan K., Baldwin, Troy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551581/
https://www.ncbi.nlm.nih.gov/pubmed/28652304
http://dx.doi.org/10.1084/jem.20170844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551581/
https://www.ncbi.nlm.nih.gov/pubmed/28652304
http://dx.doi.org/10.1084/jem.20170844

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