Cargando…

Thymic progenitors of TCRαβ(+) CD8αα intestinal intraepithelial lymphocytes require RasGRP1 for development

Strong T cell receptor (TCR) signaling largely induces cell death during thymocyte development, whereas weak TCR signals induce positive selection. However, some T cell lineages require strong TCR signals for differentiation through a process termed agonist selection. The signaling relationships tha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Golec, Dominic P., Hoeppli, Romy E., Henao Caviedes, Laura M., McCann, Jillian, Levings, Megan K., Baldwin, Troy A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551581/ https://www.ncbi.nlm.nih.gov/pubmed/28652304 http://dx.doi.org/10.1084/jem.20170844

Ejemplares similares

RasGRP1, but Not RasGRP3, Is Required for Efficient Thymic β-Selection and ERK Activation Downstream of CXCR4
por: Golec, Dominic P., et al.
Publicado: (2013)

Identification and Regulation of TCRαβ(+)CD8αα(+) Intraepithelial Lymphocytes in Murine Oral Mucosa
por: Wu, Ruiqing, et al.
Publicado: (2020)

Increased TCR signal strength in DN thymocytes promotes development of gut TCRαβ((+))CD8αα((+)) intraepithelial lymphocytes
por: Grandjean, Capucine L., et al.
Publicado: (2017)

The histone demethylase Kdm6b regulates the maturation and cytotoxicity of TCRαβ(+)CD8αα(+) intestinal intraepithelial lymphocytes
por: Zhang, Haohao, et al.
Publicado: (2022)

Regulation of membrane phospholipid asymmetry by Notch-mediated flippase expression controls the number of intraepithelial TCRαβ(+)CD8αα(+) T cells
por: Ishifune, Chieko, et al.
Publicado: (2019)

Development and function of natural TCR(+) CD8αα(+) intraepithelial lymphocytes
por: Gui, Yuanyuan, et al.
Publicado: (2022)

Non-canonicaly recruited TCRαβCD8αα IELs recognize microbial antigens
por: Wojciech, Lukasz, et al.
Publicado: (2018)

CD8αα(+) Intraepithelial Lymphocytes Arise from Two Major Thymic Precursors
por: Ruscher, Roland, et al.
Publicado: (2017)

TGF-β controls development of TCRγδ(+)CD8αα(+) intestinal intraepithelial lymphocytes
por: Han, Jiajia, et al.
Publicado: (2023)

Basal LAT-diacylglycerol-RasGRP1 Signals in T Cells Maintain TCRα Gene Expression
por: Markegard, Evan, et al.
Publicado: (2011)

Dysregulation of RasGRP1 in rheumatoid arthritis and modulation of RasGRP3 as a biomarker of TNFα inhibitors
por: Golinski, Marie-Laure, et al.
Publicado: (2015)

Function of RasGRP3 in the formation and progression of human breast cancer
por: Nagy, Zsuzsanna, et al.
Publicado: (2014)

RasGRP2 Structure, Function and Genetic Variants in Platelet Pathophysiology
por: Canault, Matthias, et al.
Publicado: (2020)

Human thymic putative CD8αα precursors exhibit a biased TCR repertoire in single cell AIRR-seq
por: Heimli, Marte, et al.
Publicado: (2023)

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1
por: Iwig, Jeffrey S, et al.
Publicado: (2013)

The Molecular Signature Underlying the Thymic Migration and Maturation of TCRαβ(+)CD4(+)CD8(-) Thymocytes
por: Teng, Fei, et al.
Publicado: (2011)

CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy
por: Komdeur, Fenne L., et al.
Publicado: (2016)

Dominant Negative FADD/MORT1 Inhibits the Development of Intestinal Intraepithelial Lymphocytes With a Marked Defect on CD8αα+TCRγδ+ T Cells
por: Zhang, Xuerui, et al.
Publicado: (2018)

RasGRP3 regulates the migration of glioma cells via interaction with Arp3
por: Lee, Hae Kyung, et al.
Publicado: (2015)

The critical role of RasGRP4 in the growth of diffuse large B cell lymphoma
por: Zhu, Lin, et al.
Publicado: (2019)

RasGRP1 induces autophagy and transformation-associated changes in primary human keratinocytes
por: Fonseca, Lauren L., et al.
Publicado: (2020)

Control of CD8αα intestinal intraepithelial lymphocyte development by TGF-β
por: Konkel, Joanne E., et al.
Publicado: (2011)

Intracellular metabolic adaptation of intraepithelial CD4(+)CD8αα(+) T lymphocytes
por: Harada, Yosuke, et al.
Publicado: (2022)

Regulation of RasGRP1 Function in T Cell Development and Activation by Its Unique Tail Domain
por: Fuller, Deirdre M., et al.
Publicado: (2012)

RasGRP3, a Ras activator, contributes to signaling and the tumorigenic phenotype in human melanoma
por: Yang, Dazhi, et al.
Publicado: (2011)

RasGRP Exacerbates Lipopolysaccharide-Induced Acute Kidney Injury Through Regulation of ERK Activation
por: Tang, Wen, et al.
Publicado: (2022)

Abnormal RasGRP1 Expression in the Post-Mortem Brain and Blood Serum of Schizophrenia Patients
por: De Rosa, Arianna, et al.
Publicado: (2022)

Lineage re-commitment of CD4CD8αα intraepithelial lymphocytes in the gut
por: Park, Yunji, et al.
Publicado: (2016)

Structural and Biophysical Insights into the TCRαβ Complex in Chickens
por: Zhang, Lijie, et al.
Publicado: (2020)

Conditional Deletion of TAK1 in T Cells Reveals a Pivotal Role of TCRαβ(+) Intraepithelial Lymphocytes in Preventing Lymphopenia-Associated Colitis
por: Sanjo, Hideki, et al.
Publicado: (2015)

An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response
por: Liu, Yan, et al.
Publicado: (2007)

RasGRP1 is a causal factor in the development of l-DOPA–induced dyskinesia in Parkinson’s disease
por: Eshraghi, Mehdi, et al.
Publicado: (2020)

RasGRP1 promotes the acute inflammatory response and restricts inflammation-associated cancer cell growth
por: Wang, Cong, et al.
Publicado: (2022)

GPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment
por: Wang, Xiaoming, et al.
Publicado: (2014)

GPR43 stimulation on TCRαβ(+) intraepithelial colonic lymphocytes inhibits the recruitment of encephalitogenic T-cells into the central nervous system and attenuates the development of autoimmunity
por: Prado, Carolina, et al.
Publicado: (2023)

Human Innate Mycobacterium tuberculosis–Reactive αβTCR(+) Thymocytes
por: Gold, Marielle C, et al.
Publicado: (2008)

Presenilins regulate αβ T cell development by modulating TCR signaling
por: Laky, Karen, et al.
Publicado: (2007)

Revisiting the Discovery of the αβ TCR Complex and Its Co-Receptors
por: Reinherz, Ellis L.
Publicado: (2014)

Characterization of human αβTCR repertoire and discovery of D-D fusion in TCRβ chains
por: Liu, Peipei, et al.
Publicado: (2014)

Nurr1 performs its anti-inflammatory function by regulating RasGRP1 expression in neuro-inflammation
por: Oh, Mihee, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ta97gb65v8ltepeu5uchpoccsl