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Regulation of brain insulin signaling: A new function for tau
In this issue of JEM, Marciniak et al. (https://doi.org/10.1084/jem.20161731) identify a putative novel function of tau protein as a regulator of insulin signaling in the brain. They find that tau deletion impairs hippocampal response to insulin through IRS-1 and PTEN dysregulation and suggest that,...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551584/ https://www.ncbi.nlm.nih.gov/pubmed/28652305 http://dx.doi.org/10.1084/jem.20170979 |
| _version_ | 1783256329063759872 |
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| author | Gratuze, Maud Planel, Emmanuel |
| author_facet | Gratuze, Maud Planel, Emmanuel |
| author_sort | Gratuze, Maud |
| collection | PubMed |
| description | In this issue of JEM, Marciniak et al. (https://doi.org/10.1084/jem.20161731) identify a putative novel function of tau protein as a regulator of insulin signaling in the brain. They find that tau deletion impairs hippocampal response to insulin through IRS-1 and PTEN dysregulation and suggest that, in Alzheimer’s disease, impairment of brain insulin signaling might occur via tau loss of function. |
| format | Online Article Text |
| id | pubmed-5551584 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | The Rockefeller University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-55515842018-02-07 Regulation of brain insulin signaling: A new function for tau Gratuze, Maud Planel, Emmanuel J Exp Med News In this issue of JEM, Marciniak et al. (https://doi.org/10.1084/jem.20161731) identify a putative novel function of tau protein as a regulator of insulin signaling in the brain. They find that tau deletion impairs hippocampal response to insulin through IRS-1 and PTEN dysregulation and suggest that, in Alzheimer’s disease, impairment of brain insulin signaling might occur via tau loss of function. The Rockefeller University Press 2017-08-07 /pmc/articles/PMC5551584/ /pubmed/28652305 http://dx.doi.org/10.1084/jem.20170979 Text en © 2017 Gratuze and Planel http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
| spellingShingle | News Gratuze, Maud Planel, Emmanuel Regulation of brain insulin signaling: A new function for tau |
| title | Regulation of brain insulin signaling: A new function for tau |
| title_full | Regulation of brain insulin signaling: A new function for tau |
| title_fullStr | Regulation of brain insulin signaling: A new function for tau |
| title_full_unstemmed | Regulation of brain insulin signaling: A new function for tau |
| title_short | Regulation of brain insulin signaling: A new function for tau |
| title_sort | regulation of brain insulin signaling: a new function for tau |
| topic | News |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551584/ https://www.ncbi.nlm.nih.gov/pubmed/28652305 http://dx.doi.org/10.1084/jem.20170979 |
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